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| 1850 |
| | Brazil, historically the world's second largest importer of slaves from Africa, finally bans the slave trade | |
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| 1852 |
| | US entrepreneur Cornelius Vanderbilt conveys passengers across the American continent through Nicaragua by steamship and horse and carriage | |
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| 1852 |
| | In an Argentinian civil war, Urquiza defeats the dictator Rosas and is subsequently elected president (in 1854) | |
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| 1855 |
| | Jamaican-born nurse Mary Seacole sets up her own 'British Hotel' in the Crimea to provide food and nursing for soldiers in need | |
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| 1855 |
| | The Panama Railroad company completes a line between the Atlantic and the Pacific, providing America's first transcontinental link | |
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| 1855 |
| | Liberal leaders Juan Alvarez and Ignacio Comonfort launch a political programme in Mexico that becomes know simply as 'the Reform' | |
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| 1856 |
| | An American adventurer, William Walker, wins control of the government in Nicaragua and for a year rules as president | |
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| 1858 |
| | Conservatives seize Mexico City at the start of a civil war against the Liberal government | |
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| 1860 |
| | US adventurer William Walker, thrown out of Nicaragua in 1857, is executed in Honduras | |
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| 1861 |
| | The Liberals recover Mexico City and elect Benito Juarez as president | |
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